Does C50.321 require prior authorization?

No, C50.321 does not require prior authorization (high confidence). Code is covered without prior authorization.

`C50.321` — Malignant neoplasm of lower-inner quadrant of right male breast

ICD-10-CM

No Prior Auth Required

Code is covered without prior authorization (high confidence)

Enter '1' in the Days/Unit field on the claim when billing for MammaPrint®.
For CPT non-NOC codes, submit required information using SV101-7 or SV202-7 (preferred) or the NTE field.
Enter the appropriate DEX Z-Code™ identifier adjacent to the CPT code in the comment/narrative field for Part B claims (Loop 2400 or SV101-7 for 837P; Box 19 for paper claims).
Enter the appropriate DEX Z-Code™ identifier adjacent to the CPT code in the comment/narrative field for Part A claims (Line SV202-7 for 837I electronic claim; Block 80 for UB04).

MammaPrint® is indicated to analyze gene expression of FFPE breast cancer tissue to assess a patient's risk for distant metastasis (early-stage breast cancer).
The test may be performed using either the FDA-cleared microarray assay or a next-generation sequencing (NGS)-based assay.
PIK3CA targeted gene sequencing is indicated to detect PIK3CA mutations in patients with hormone receptor (HR)-positive, HER2-negative, advanced or metastatic breast cancer (postmenopausal women and men) who have progressed on or after an endocrine-based regimen when results will inform treatment with alpelisib (Piqray).
Germline testing is covered when the patient has ovarian, breast, pancreatic, or prostate cancer and meets clinical indication for immediate treatment with an FDA‑approved PARP inhibitor.
Testing for deleterious variants in homologous recombination repair (HRR) genes (e.g., BRCA1, BRCA2) is covered as an aid when results will be used to determine eligibility for PARP inhibitor therapy.
Limited germline testing of a select group of genes (rather than a comprehensive panel) is covered when the patient does not meet criteria for larger panel testing per LCD L39040 and limited testing is necessary to comply with FDA indicated drug usage.

L34648 — Bisphosphonate Drug Therapy

J05

L39051 — Cosmetic and Reconstructive Surgery

J05

A58774 — Billing and Coding: Cosmetic and Reconstructive Surgery

J05

L38678 — MolDX: Phenotypic Biomarker Detection from Circulating Tumor Cells

J05

A58756

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