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MolDX: Oncotype DX® Colon Cancer Assay Update
A53106
Effective: February 26, 2018
Updated: December 31, 2025
Policy Summary
The Oncotype DX Colon Cancer Assay (CPT 81525) is intended to predict recurrence risk for patients with Stage II colon cancer. Billing requires CPT 81525, entering '1' in the Days/Unit field, submission of the appropriate DEX Z-Code adjacent to the CPT code in specified claim fields (SV101-7/SV202-7/NTE/Loop 2400/Box 19/Block 80), and selection of the appropriate ICD-10-CM diagnosis code.
Coverage Criteria Preview
Key requirements from the full policy
"Oncotype DX Colon Cancer Assay is indicated to predict recurrence risk for patients with Stage II colon cancer."
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