Billing and Coding: MolDX: SEPT9 Gene Test

The SEPT9 (Septin 9 methylation) test (CPT 81327) for colorectal cancer detection or screening is a statutorily excluded service and is not covered by Medicare. To receive a denial, submit claims with CPT 81327, indicate excluded services with modifier GY (use GX only for a voluntary ABN), and include the DEX Z‑Code™ adjacent to the CPT in the specified Part A and Part B claim fields.

"Septin 9 (SEPT9) methylation analysis for colorectal cancer detection (CPT 81327) is a statutorily excluded service and is not covered by Medicare."

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