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Billing and Coding: MolDX: BluePrint® Test
A54257
Effective: November 16, 2023
Updated: December 31, 2025
Policy Summary
BluePrint® molecular subtyping assay is statutorily excluded from Medicare coverage because evidence of clinical utility is insufficient; it is not a covered benefit. Claims should use CPT 81479, indicate the exclusion with modifier GY (use GX only if a voluntary ABN is issued), include the appropriate Z-code in the specified claim loops or paper form locators, and submit only one test identifier per paper claim.
Coverage Criteria Preview
Key requirements from the full policy
"BluePrint® molecular subtyping assay is statutorily excluded from Medicare coverage due to insufficient evidence of clinical utility and is not a covered benefit."
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