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Billing and Coding: MolDX: Oncotype DX® Breast Cancer Assay
A54480
Effective: November 1, 2019
Updated: December 31, 2025
Policy Summary
Oncotype DX Breast is intended for ER-positive invasive breast cancer patients who are node-negative, have nodal micrometastases, or have 1–3 positive lymph nodes. Billing requires entering '1' in Days/Unit, reporting the appropriate ICD-10-CM code, and including the Z-Code Identifier in specified Part A and Part B claim narrative fields; DCIS-related tests and codes are excluded and must not share the same Z-Code.
Coverage Criteria Preview
Key requirements from the full policy
"Oncotype DX Breast is indicated for patients with estrogen-receptor (ER) positive, node-negative invasive breast carcinoma."
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