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Billing and Coding: MolDX: Oncotype DX® Colon Cancer
A54486
Effective: November 1, 2019
Updated: December 31, 2025
Policy Summary
This billing/coding policy specifies claim-level requirements for the Oncotype DX Colon Cancer Assay, which is intended for assessing recurrence risk in Stage II colon cancer. Claims must report one unit of service, include the appropriate DEX Z-Code adjacent to the CPT code in the specified Part A/Part B fields (Loop 2400/SV101-7/Item 19 for Part B; SV202-7/Block 80 for Part A), and select the appropriate ICD-10-CM diagnosis code.
Coverage Criteria Preview
Key requirements from the full policy
"Use the Oncotype DX Colon Cancer Assay for patients with Stage II colon cancer to assess recurrence risk."
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