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Billing and Coding: Intravenous Immune Globulin (IVIg)-NCD 250.3
A54641
Effective: November 7, 2015
Updated: December 31, 2025
Policy Summary
CMS covers IVIg when the patient meets at least one of: failed conventional therapy, contraindication to conventional therapy, or rapidly progressive disease requiring temporary IVIg while awaiting effect of conventional agents. IVIg for autoimmune mucocutaneous blistering disease is limited to short-term use and not allowed as maintenance; specific definitions of 'failure,' 'contraindication,' and 'short-term' are determined by contractors.
Coverage Criteria Preview
Key requirements from the full policy
"Patient has failed conventional therapy."
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