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Billing and Coding: MolDX: HTTLPR Gene Testing
A55169
Wisconsin Physicians Service Insurance Corporation (J05)
Effective: October 30, 2025
Updated: December 31, 2025
Policy Summary
HTTLPR (serotonin transporter) genotyping is statutorily excluded from Medicare coverage for dates of service on or after 2013-06-26 and is not covered under Part A or Part B. To obtain a service denial, submit CPT 81479 and follow specific billing instructions (DEX Z-Code adjacent to CPT, use SV101-7/SV202-7 or NTE fields); an ABN is not required but if voluntarily issued use GX or GY modifiers as specified.
Coverage Criteria Preview
Key requirements from the full policy
"HTTLPR (serotonin transporter) genotyping testing is statutorily excluded and is not covered by Medicare for dates of service on or after 2013-06-26."
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