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Billing and Coding: MolDX: HTTLPR Gene Testing
A55264
Effective: December 17, 2021
Updated: December 31, 2025
Policy Summary
HTTLPR (serotonin transporter) gene testing is statutorily excluded and not covered due to insufficient evidence. To obtain a formal denial submit CPT 81479 and follow claim-entry instructions (DEX Z-Code placement); an ABN is not required but use GX for voluntary ABN and GY to indicate an ABN on file.
Coverage Criteria Preview
Key requirements from the full policy
"No clinical indications are covered; HTTLPR (serotonin transporter) gene testing is statutorily excluded and not covered due to insufficient evidence."
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