Billing and Coding: Flow Cytometry

Medicare covers flow cytometry procedures with specific CPT codes for DNA ploidy/S‑phase analysis (88182), immunophenotyping technical components (88184, 88185), interpretation (88187–88189), and quantitative cell counts (86355–86367) subject to coding edits. Billing must follow rules against duplicate testing and incompatible code combinations (e.g., do not combine 86355–86367 with 88187–88189 or 88184/88185 for the same analysis), include valid ICD‑10 diagnoses and required ordering/referring physician information, and comply with ABN/modifier and documentation requirements (CMS‑R‑131, occurrence code 32 for Part A MAC as applicable).

"CPT 88182 reports the physician professional and facility technical components of DNA ploidy and S-phase analysis of tumor by flow cytometry."

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