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Billing and Coding: MolDX: Breast Cancer Index® (BCI) Gene Expression Test
A56875
Effective: October 9, 2021
Updated: December 31, 2025
Policy Summary
MolDX covers the Breast Cancer Index (BCI) gene expression test for postmenopausal women with early-stage (T1-T3, pN0-pN1, M0) invasive breast carcinoma that is ER-positive and/or PR-positive and HER2-negative when results will guide chemotherapy and/or endocrine therapy. The test must use FFPE primary tumor tissue obtained prior to adjuvant treatment, is expected once per patient lifetime, and should be billed with CPT 81518 (1 unit) including the appropriate DEX Z-Code and ICD-10-CM diagnosis on the claim.
Coverage Criteria Preview
Key requirements from the full policy
"Patient is postmenopausal."
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