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Billing and Coding: MolDX: EndoPredict Breast Cancer Gene Expression Test
A56963
Effective: November 4, 2021
Updated: December 31, 2025
Policy Summary
Billing for the MolDX EndoPredict breast cancer gene expression test requires use of CPT code 81522 with one unit of service. Claims must include the appropriate DEX Z-Code adjacent to the CPT code in specified electronic or paper fields (Part B: Loop 2400/SV101-7 or Box 19; Part A: SV202-7 or UB04 Block 80) and report an appropriate ICD-10-CM diagnosis code. No clinical coverage indications or explicit exclusions are specified in this billing/coding guidance.
Coverage Criteria Preview
Key requirements from the full policy
"Report EndoPredict using CPT code 81522 on the claim."
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