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Billing and Coding: MolDX: Breast Cancer Assay: Prosigna®
A57363
Effective: April 22, 2021
Updated: December 31, 2025
Policy Summary
Prosigna® billing requires reporting CPT code 81520 with 1 unit of service and inclusion of the appropriate ICD-10-CM diagnosis code. A DEX Z-Code identifier must be entered adjacent to the CPT code in the claim narrative using the specified fields for Part B (Loop 2400 / SV101-7 for 837P or Box 19 paper) and Part A (SV202-7 for 837I or Block 80 on UB04).
Coverage Criteria Preview
Key requirements from the full policy
"Report the Prosigna® assay using CPT code 81520 on the claim."
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Covered Medical Codes