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Billing and Coding: MolDX: EndoPredict® Breast Cancer Gene Expression Test
A57607
Effective: November 4, 2021
Updated: December 31, 2025
Policy Summary
To bill the EndoPredict breast cancer gene expression test, report CPT code 81522 and enter one unit of service, include the appropriate DEX Z-Code adjacent to the CPT code in the specified comment/narrative fields for Part A and Part B claims, and report the appropriate ICD-10-CM diagnosis code. Use the designated electronic loops/segments (837P Loop 2400/SV101-7, 837I SV202-7) or paper fields (Item 19 for CMS-1500, Block 80 for UB04) as directed.
Coverage Criteria Preview
Key requirements from the full policy
"Report CPT code 81522 to bill for the EndoPredict breast cancer gene expression test."
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