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Billing and Coding: MolDX: EndoPredict® Breast Cancer Gene Expression Test
A57608
Effective: November 4, 2021
Updated: December 31, 2025
Policy Summary
This billing/coding guidance instructs providers to report the EndoPredict® Breast Cancer Gene Expression Test using CPT code 81522 with 1 unit of service and to include the appropriate DEX Z-Code adjacent to the CPT code in specified claim fields for Part A and Part B claims. Providers must also select an appropriate ICD-10-CM diagnosis code; clinical coverage and medical necessity criteria are not included here and must be confirmed in the MolDx LCD for EndoPredict.
Coverage Criteria Preview
Key requirements from the full policy
"Billing guidance applies to the EndoPredict® Breast Cancer Gene Expression Test when reported using CPT code 81522."
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