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Billing and Coding: MolDX: Next-Generation Sequencing for Solid Tumors
A57905
Effective: April 1, 2025
Updated: December 31, 2025
Policy Summary
To bill Next-Generation Sequencing for solid tumors, report the appropriate CPT code with 1 unit of service, include the applicable DEX Z-Code identifier adjacent to the CPT code in the specified claim field depending on claim type (Loop 2400/SV101-7 for 837P, Item 19 for paper, SV202-7 for 837I, Block 80 for UB04), and include the appropriate ICD-10-CM diagnosis code. Do not add extra characters or additional information when entering the DEX Z-Code on the SV101-7 field.
Coverage Criteria Preview
Key requirements from the full policy
"Submit the CPT code that corresponds to the performed Next-Generation Sequencing (NGS) for solid tumors on the claim."
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