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Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma
A59109
Effective: August 6, 2023
Updated: December 31, 2025
Policy Summary
Molecular assays for diagnosis of cutaneous melanoma are billable when coded per the MolDX instructions: myPath assays use CPT 81479 for dates of service before 2019-07-01 and CPT 0090U on/after 2019-07-01; other assays may use 81479 only if no specific CPT/PLA exists. Only one test may be billed per patient per melanocytic lesion (report 1 UOS), and the appropriate DEX Z-Code and ICD-10-CM diagnosis code must be submitted in the specified claim fields.
Coverage Criteria Preview
Key requirements from the full policy
"Molecular assays for the diagnosis of cutaneous melanoma are billable when submitted with the appropriate CPT/PLA code per these coding instructions."
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