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Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma
A59181
Effective: August 6, 2023
Updated: December 31, 2025
Policy Summary
This billing/coding guidance covers molecular assays used to diagnose cutaneous melanoma, including myPath®Melanoma and other assays. Use CPT 81479 for myPath tests before 2019-07-01 and CPT 0090U on/after 2019-07-01; use 81479 for other assays if no applicable CPT/PLA code exists, bill one unit and only one test per patient per melanocytic lesion, and include the appropriate DEX Z-Code identifier and ICD-10-CM diagnosis code in the specified claim fields.
Coverage Criteria Preview
Key requirements from the full policy
"Molecular assays performed for the diagnosis of cutaneous melanoma (including myPath®Melanoma and other molecular assays) may be billed under this guidance."
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