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Billing and Coding: MolDX: Molecular Assays for the Diagnosis of Cutaneous Melanoma
A59261
Wisconsin Physicians Service Insurance Corporation (J05)
Effective: September 25, 2025
Updated: December 31, 2025
Policy Summary
This billing/coding guideline covers molecular assays used to diagnose cutaneous melanoma and provides CPT code selection and claim submission instructions. Key rules: use CPT 81479 for myPath before 2019-07-01 and CPT 0090U on/after 2019-07-01, bill only one test (1 UOS) per patient per melanocytic lesion, include the appropriate DEX Z-Code in specified claim fields, and report the appropriate ICD-10-CM diagnosis code.
Coverage Criteria Preview
Key requirements from the full policy
"Molecular assays for the diagnosis of cutaneous melanoma are billable when submitted with the appropriate CPT or PLA code for the specific assay."
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