Payer PolicyActive
Tumor Chemosensitivity Assays
AETNA-CPB-0245
Aetna
Effective: March 29, 2023
Updated: December 6, 2025
created · Dec 2, 2025
Policy Summary
Aetna excludes tumor chemosensitivity assays (e.g., ChemoFx, DiSC, Cytoprint, HTCA, MTT, MiCK/CorrectChemo, NexGen Cancer Cytotoxicity, 3D Predict Glioma, Reverse Phase Protein Array and specified CPT/HCPCS/test codes) as experimental and investigational because there is insufficient reliable evidence that they change management or improve clinical outcomes. Use is not recommended outside clinical trials per ASCO/NCCN guidance and no prospective trials have shown survival benefit.
Coverage Criteria Preview
Key requirements from the full policy
"Explicit technologies/procedures designated investigational (no covered indications listed): ChemoFx assay; differential staining cytotoxicity (DiSC) assay; fluorescence (Cytoprint) assay; human tu..."
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