Plasmapheresis/Plasma Exchange/Therapeutic Apheresis

Covered for plasmapheresis/plasma exchange for acute antibody‑mediated renal transplant rejection, acute severe MS relapses refractory to high‑dose glucocorticoids, ANCA‑associated vasculitis unresponsive to conventional therapy, catastrophic antiphospholipid syndrome, and red blood cell exchange for babesiosis with high‑grade parasitemia (≥10%), hemoglobin ≤10 g/dL, or hepatic/pulmonary/renal compromise; leukapheresis (CPT 36511) is covered only for acute debulking. All other indications are considered experimental/investigational and not covered (including chronic/secondary progressive MS maintenance, Miller Fisher syndrome, HDL delipidation/plasma reinfusion CPT 0342T, and the extensive list of other disorders).

"Essential thrombocythemia when platelet count is >1,000,000/mm3 (platelet pheresis)"

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