Payer PolicyActive
Chronic Fatigue Syndrome
AETNA-CPB-0369
Aetna
Effective: June 21, 2023
Updated: December 6, 2025
created · Dec 2, 2025
Policy Summary
Aetna covers as medically necessary exclusionary tests for evaluating suspected chronic fatigue syndrome: ANA, basic blood/serum chemistries (BUN, calcium, creatinine, glucose, electrolytes) and CBC with differential, with the specific tests selected based on case characteristics. Aetna considers ACTH stimulation testing, blood and CSF cytokine assays, ELISA/ACT testing, enteric dysbiosis evaluation, and metabolomics (blood/urine) experimental/investigational and not covered.
Coverage Criteria Preview
Key requirements from the full policy
"HCPCS/Codes not covered (selected list): C9723 (DIRI), G0237 (breathing retraining), J0133 (acyclovir injection) and a long list of J-codes for immune globulins, steroids, rituximab (J9312), ondans..."
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