Payer PolicyActive
Oral and Esophageal Brush Biopsy
AETNA-CPB-0686
Aetna
Effective: September 15, 2023
Updated: December 6, 2025
created · Dec 2, 2025
Policy Summary
Aetna considers oral brush biopsy (e.g., OralCDx), esophageal brush biopsy/WATS‑3D (including adjunctive use with forceps biopsies), DNA‑image cytometry, and RNA‑based oral brush assays experimental and investigational and therefore not covered for screening, diagnosis, or surveillance of oral or esophageal precancerous lesions or cancer. No indications are listed as covered because effectiveness has not been established.
Coverage Criteria Preview
Key requirements from the full policy
"None listed as covered. The policy states the procedures described below are considered experimental and investigational and therefore not established as effective."
Sign up to see full coverage criteria, indications, and limitations.