Concert Genetic Testing: Aortopathies and Connective Tissue Disorders

This policy covers Concert genetic testing (single-gene and multigene panels) for evaluation and diagnosis of hereditary aortopathies and connective tissue disorders—including Marfan syndrome, Loeys‑Dietz syndrome, vascular and classic Ehlers‑Danlos syndromes—and for patients with thoracic aortic aneurysm/dissection, congenital musculoskeletal anomalies, or syndromic features when results would affect aortic surveillance, surgical planning, or multisystem management. Coverage is limited to disorders with a known genetic basis and requires meeting specified clinical criteria, relevant family history, or an expected change in management; testing for hypermobile Ehlers‑Danlos syndrome (hEDS) is not covered and many panels are investigational for indications not explicitly listed, with other requests evaluated case‑by‑case per the General Approach.

"Genetic testing for hereditary connective tissue disorders when clinical features suggest a HCTD (e."