Neonatal Sepsis Management

This policy covers evaluation and management of neonatal sepsis—including culture‑proven Group B Streptococcus early‑onset (0–6 days) and late‑onset (7–89 days), suspected sepsis in any newborn, antibiotic therapy, level‑of‑care placement (Levels I/II/III/transitional) and criteria for discharge or home IV/IM therapy. It applies to symptomatic infants meeting Level III criteria (clinical signs of sepsis, temperature ≥100.4°F or ≤96.8°F, and on/awaiting 48 hours of antibiotics), well‑appearing/asymptomatic infants on empiric antibiotics, and culture‑confirmed GBS infections. Major limitations/requirements: Level III and prolonged inpatient stays require specified clinical criteria and culture confirmation; empiric antibiotics generally should not continue beyond 48 hours if cultures are sterile, Level II is limited to asymptomatic infants pending cultures ≤2 days, and home IV therapy mandates clinical stability, secure IV access, a qualified home‑infusion agreement, and follow‑up within 48 hours.