Payer PolicyActive
LAB.00028 Blood-based Biomarker Tests for Multiple Sclerosis
ANTHEM-LAB.00028
Anthem
Effective: December 18, 2025
Updated: December 30, 2025
Policy Summary
This policy addresses blood-based biomarker tests for multiple sclerosis (MS), including use for diagnosis, prognosis, or disease management. Anthem considers these tests investigational and not medically necessary; they are not covered for any indication. Non-coverage applies to all clinical scenarios (including MS and clinically isolated syndrome) and may be reported with CPT/HCPCS codes 81599, 83884, 84999 and ICD-10 codes G35.A, G35.D, G37.9.
Coverage Criteria Preview
Key requirements from the full policy
"Blood-based biomarker tests for multiple sclerosis are consideredinvestigational and not medically necessaryfor all uses."
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