Payer PolicyActive
LAB.00033 Protein Biomarkers for the Screening, Detection and Management of Prostate Cancer
ANTHEM-LAB.00033
Anthem
Effective: December 18, 2025
Updated: December 30, 2025
Policy Summary
- Service addressed: Blood- or urine-based protein biomarker laboratory tests used for the screening, detection, risk stratification, or management of prostate cancer (e.g., assays billed under 81479, 81539 and related L-codes). - Coverage determination: Anthem considers these tests investigational/experimental and not medically necessary; therefore, they are not covered. - Key limitations: There are no covered indications—noncoverage applies to all clinical scenarios and assay types (screening, diagnosis, risk stratification, and monitoring).
Coverage Criteria Preview
Key requirements from the full policy
"The use of protein biomarker tests for the screening, detection, and management of prostate cancer is consideredinvestigational and not medically necessary."
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