Payer PolicyActive
LAB.00044 Saliva-based Testing to Determine Drug-Metabolizer Status
ANTHEM-LAB.00044
Anthem
Effective: April 16, 2025
Updated: December 30, 2025
Policy Summary
- Service: Saliva-based testing to determine drug-metabolizer status (e.g., assays assessing CYP450 enzyme activity). - Coverage: Anthem considers these tests investigational and not medically necessary; they are not covered for any indication. - Limitations: No covered circumstances or exceptions—this applies to all saliva-based assays used to assess metabolizer status, regardless of condition, drug, or test brand.
Coverage Criteria Preview
Key requirements from the full policy
"Saliva-based testing to determine drug-metabolizer status is consideredinvestigational and not medically necessaryfor all indications."
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