Payer PolicyActive
SURG.00126 Irreversible Electroporation
ANTHEM-SURG.00126
Anthem
Effective: December 18, 2025
Updated: December 30, 2025
Policy Summary
This policy addresses irreversible electroporation (IRE) ablation of soft tissue or solid organs (e.g., liver, pancreas, prostate), including use of the NanoKnife system. Anthem considers IRE investigational and not medically necessary for these uses; therefore, it is not covered. There are no covered indications, and related claims (e.g., CPT/HCPCS 00126, 47384, 55877, 93799, S0748) are subject to denial as investigational.
Coverage Criteria Preview
Key requirements from the full policy
"Irreversible electroporation is consideredinvestigational and not medically necessaryfor ablation of soft tissue orof solid organs including, but not limited to, the liver, pancreas, and prostate."
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