Payer PolicyActive
Histrelin acetate subcutaneous implant (Supprelin® LA)
EVICORE-MEDICAL_DRUG-12EA28F1
EviCore by Evernorth
Effective: December 1, 2022
Updated: January 13, 2026
created · Dec 4, 2025
Policy Summary
Supprelin LA (histrelin acetate 50 mg subcutaneous implant) is covered only for children with the FDA‑approved indication of central precocious puberty; other indications are excluded. Authorization is for 12 months with the recommended 50 mg implant placed subcutaneously in the upper arm once every 12 months, and documentation of the CPP diagnosis and that the patient meets the FDA‑approved coverage criteria is required.
Coverage Criteria Preview
Key requirements from the full policy
"Treatment of children with central precocious puberty (FDA-approved indication)."
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