Payer PolicyActive
Edaravone Injection (Radicava)
EVICORE-MEDICAL_DRUG-65E089E8
EviCore by Evernorth
Effective: May 1, 2020
Updated: January 13, 2026
created · Dec 4, 2025
Policy Summary
Radicava (edaravone) is covered only for the FDA‑approved indication of ALS (other uses excluded) in patients with a "definite" or "probable" ALS diagnosis per El Escorial/revised Airlie House criteria. Coverage requires ALSFRS‑R ≥2 on every item, percent‑predicted FVC ≥80%, diagnosis ≤2 years, prior or current riluzole therapy, prescription by or in consultation with an ALS specialist; initial authorization is 6 months and reauthorization (1 year) requires documented ongoing benefit and no invasive ventilation.
Coverage Criteria Preview
Key requirements from the full policy
"Only patients with the FDA-approved indication (ALS) are eligible; other uses are not supported by these coverage guidelines."
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