Payer PolicyActive
Amtagvi (lifileucel) - MEDICAID - FLORIDA
HUMANA-AMTAGVI-LIFILEUCEL-FL-MEDICAID
Humana
Effective: November 5, 2025
Updated: December 13, 2025
Policy Summary
This policy covers Amtagvi (lifileucel), an autologous tumor‑infiltrating lymphocyte (TIL) immunotherapy for adults with unresectable or metastatic melanoma. Coverage is limited to individuals ≥18 years who have progressed on a PD‑1 inhibitor (and, if BRAF V600–mutant, a BRAF inhibitor ± MEK inhibitor), requires medical‑director review/prior authorization through the Corporate Transplant Department, excludes other indications and pregnancy/intent to reproduce, and notes that evidence is limited.
Coverage Criteria Preview
Key requirements from the full policy
"Documentation verifying patient age (18 years of age or older)"
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