Vitamin B₁₂ Injections

Vitamin B12 injections are covered when there is a documented history of low serum B12 or diagnoses causing/caused by B12 deficiency, and when used as adjunctive supplementation for pemetrexed or pralatrexate per specified timing. For pemetrexed give one IM dose within the week before the first dose and every three cycles; for pralatrexate give 1 mg IM ≤10 weeks before the first dose and every 8–10 weeks thereafter. Injections to strengthen foot tendons/ligaments are noncovered and all services must meet CMS medical necessity and documentation/audit requirements.

"Vitamin B12 injection is covered when the beneficiary has a documented history of a low serum vitamin B12 level."

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