Homocysteine Level, Serum

Medicare covers serum homocysteine testing to confirm vitamin B12 or folate deficiency when initial B12/folate test results are inconclusive or discordant with clinical findings. Homocysteine testing is also covered for one-time lifetime risk stratification only in patients with known vascular disease or vascular risk factors (abnormal lipids, hypertension, or diabetes); testing for screening in patients without vascular disease or for evaluation of treatment of hyperhomocysteinemia (including in osteoporosis or primary fracture prevention) is not covered.

"Measure serum homocysteine to confirm vitamin B12 or folate deficiency when initial vitamin B12 and/or folate test results are inconclusive or when clinical findings are inconsistent with initial t..."

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