MolDX: HLA-DQB1*06:02 Testing for Narcolepsy

HLA-DQB1*06:02 typing (CPT 81383) is considered experimental/investigational and is not covered for the diagnosis or management of narcolepsy for any population. The test is insufficient to confirm or exclude narcolepsy or to quantify individual risk due to its limited sensitivity and specificity (15–25% carrier rate in unaffected persons and absence in some affected individuals), and therefore has no demonstrated clinical utility in diagnosis or treatment.

"HLA-DQB1*06:02 typing (CPT 81383) for the diagnosis or management of narcolepsy is considered experimental, investigational, or unproven and is not covered for any population."

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