LCDActive
Lab: Bladder/Urothelial Tumor Markers
L36678
Effective: November 6, 2025
Updated: December 31, 2025
Policy Summary
Bladder tumor marker assays listed as covered (BTA TRAK/BTA stat, NMP-22, NMP-22 BladderChek, UroVysion FISH, ImmunoCyt) are covered only as adjuncts to cystoscopy for evaluation of symptomatic patients or surveillance of known urothelial carcinoma, and may be used in certain exceptions when cystoscopy is not possible. Markers are not covered for routine screening of all patients with hematuria and should not be performed until other diagnostic studies fail to identify the cause; numerous other marker assays are considered investigational and are not covered.
Coverage Criteria Preview
Key requirements from the full policy
"Bladder tumor marker testing (BTA TRAK/BTA stat, NMP-22 quantitative, NMP-22 BladderChek, UroVysion FISH, ImmunoCyt) is covered when performed as an adjunct to cystoscopy to evaluate patients with ..."
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