In Vitro Chemosensitivity & Chemoresistance Assays

Chemosensitivity and chemoresistance assays — including DiSC, ATP, MTT, HDRA®, EVA‑PCD®, Oncotech EDR® and similar tests — are investigational and not covered by Medicare for any cancer type or clinical scenario. Because they lack sufficient evidence of improved health outcomes, they must not be used to direct routine oncology therapy, Medicare payment is not allowable (see associated Billing & Coding Article for codes), and any documentation should be maintained in the patient’s medical record.

"None — this is a noncoverage LCD. Chemosensitivity and chemoresistance assays (CSRAs) are not covered by Medicare."

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