LCDActive
MolDX: Breast Cancer Index® (BCI) Gene Expression Test
L37794
Effective: July 3, 2025
Updated: December 31, 2025
Policy Summary
The Breast Cancer Index (BCI) test is covered only for postmenopausal women with invasive, ER+ and/or PR+, HER2- early-stage breast cancer (TNM T1-T3, pN0-pN1, M0) with no distant metastasis. Coverage requires that test results will be used to inform decisions about adding chemotherapy and/or extending endocrine therapy to estimate distant recurrence risk and endocrine responsiveness. Coverage is excluded for premenopausal women, males, tumors not meeting receptor/HER2 criteria, metastatic or relapsed disease, and situations where results will not guide treatment decisions.
Coverage Criteria Preview
Key requirements from the full policy
"Covered for postmenopausal women with invasive carcinoma of the breast."
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