LCDActive
MolDX: Melanoma Risk Stratification Molecular Testing
L38016
Effective: June 26, 2025
Updated: December 31, 2025
Policy Summary
Molecular diagnostic tests for melanoma risk stratification are covered when the patient has a personal history of melanoma, is non‑metastatic, is undergoing workup or treatment evaluation, and meets staging thresholds (T1b+ or T1a with inadequate microstaging) with a presumed SLNB risk >5%. Coverage also requires that the specific test fall within its intended use and have a Technical Assessment demonstrating clinical validity, clinical utility beyond standard factors, analytical validity, and comparable or superior performance to other covered tests.
Coverage Criteria Preview
Key requirements from the full policy
"Patient has a personal history of melanoma."
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