Amniotic and Placental-Derived Product Injections and/or Applications for Musculoskeletal Indications, Non-Wound

All injections or applications of amniotic membrane, amniotic fluid, or other placental‑derived products for musculoskeletal (non‑wound) indications—including intraoperative and non‑operative uses—are non‑covered by Medicare under this LCD (burns, wounds, ophthalmic conditions are outside its scope; dental uses are also not a Medicare benefit). No specific documentation or approval pathway is provided; non‑coverage is based on insufficient high‑quality evidence, lack of product standardization, and regulatory concerns about FDA premarket approval/clearance for internal/off‑label uses, so these indications are considered experimental/investigational.

"None — This is a NON-coverage policy for all amniotic membrane, amniotic fluid or other placental-derived product injections and/or applications as a means of managing musculoskeletal injuries, joi..."

Sign up to see full coverage criteria, indications, and limitations.