MolDX: Genetic Testing for Heritable Thoracic Aortic Disease

Genetic testing for heritable thoracic aortic disease is covered for germline tests that have completed a MolDX Technical Assessment when the patient has an aortic root or ascending aortic dilation/aneurysm/dissection and at least one qualifying risk feature (age <60, syndromic features of Marfan/Loeys‑Dietz/vascular Ehlers‑Danlos, or relevant first-/second‑degree family history including unexplained early sudden death). Coverage requires that counseling was offered, the test includes ClinGen/ACC‑AHA–recommended gene/variant content that can be reasonably detected, single‑variant testing is limited to known familial variants, and testing must not conflict with repeat germline testing provisions in policy L38274.

"Genetic testing for heritable thoracic aortic disease is covered when the patient has aortic root or ascending aortic dilation, aneurysm, or dissection as defined by national consensus guidelines, ..."