MolDX: Genetic Testing for Heritable Thoracic Aortic Disease

Coverage is provided for hereditary germline genetic testing for heritable thoracic aortic disease when the patient has aortic root/ascending aortic dilation, aneurysm, or dissection per national guidelines and at least one high-risk feature (presentation <60 years, Marfan/Loeys-Dietz/vascular Ehlers-Danlos features, relevant first- or second-degree family history, or unexplained early sudden death). Tests must include the minimum gene/variant content required by ClinGen and ACC/AHA, be limited to appropriate germline content (single-variant testing allowed only for known familial variants), and must have completed a MolDX Technical Assessment; documentation that counseling was offered is required.

"Genetic testing for heritable thoracic aortic disease is covered when the patient has an aortic root or ascending aortic dilation, aneurysm, or dissection (per national consensus guidelines) and at..."