Measurement of Long Chain Omega-3 Fatty Acids in Red Blood Cell Membranes as a Cardiac Risk Factor

This policy concerns measurement of long‑chain omega‑3 fatty acids in red blood cell membranes as a proposed cardiac risk factor and considers the test experimental/investigational and not supported for improving patient management. Although the policy notes general recommendations to increase fish intake for patients with coronary artery disease and mentions adjunctive EPA use with statins in hypercholesterolemia (JELIS), it is currently inactive and cites insufficient evidence of clinical benefit, no established diagnostic thresholds, limited generalizability of studies, and no national Medicare coverage (local contractors may decide).

"No supported indications — measurement of red blood cell membrane omega-3 fatty acids is not supported for improving patient management or risk prediction due to insufficient evidence."

Sign up to see full coverage criteria, indications, and limitations.