NCDActive
Blood Brain Barrier Osmotic Disruption for Treatment of Brain Tumors
NCD319
Effective: March 20, 2007
Updated: December 31, 2025
Policy Summary
Medicare national coverage excludes osmotic blood-brain barrier disruption (BBBD) when used as part of a treatment regimen for brain tumors; this non-coverage is effective for services on or after March 20, 2007. This determination does not change Medicare coverage of anti-cancer chemotherapy, which remains governed by existing policy.
Coverage Criteria Preview
Key requirements from the full policy
"Osmotic blood-brain barrier disruption (BBBD) used as part of a treatment regimen for brain tumors is not reasonable and necessary and is nationally non-covered for services performed on or after 2..."
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