Saturation Biopsy for Diagnosis, Staging and Management of Prostate Cancer, Including Comprehensive 3D Mapping with Biopsy

Saturation prostate biopsy, including comprehensive 3‑D mapping, is covered for diagnosis, staging, and management of prostate cancer—used for initial or repeat extensive sampling and to guide treatment or active surveillance in men with indications such as persistently rising PSA, prior non‑diagnostic TRUS biopsy within 12 months (including atypia, high‑grade PIN, or palpable lesions), or to better characterize multifocal or anterior disease. Major limitations/requirements: repeat saturation biopsies generally require a non‑diagnostic TRUS biopsy performed within the prior 12 months, the technique and core count lack standardization (commonly >20 cores), transperineal/template mapping is more invasive (often requiring general/spinal anesthesia), and use for indications beyond those listed is considered investigational/unproven.

"Saturation biopsy for diagnosis of prostate cancer when initial evaluation indicates need for extensive sampling"