Amniotic and Placental-Derived Product Injections and/or Applications for Musculoskeletal Indications, Non-Wound

LCD L39139 states that Medicare does not cover injections or applications of amniotic- or placental-derived products for any musculoskeletal (non-wound) indications because of limited evidence and lack of standardization. The policy excludes burns, wounds, and ophthalmic uses from this guidance and references FDA regulatory criteria (Section 361) and CMS NCD 110.23 as relevant external guidance for product regulatory status.

"No amniotic membrane, amniotic fluid, or other placental-derived product injections or applications are covered for musculoskeletal indications (non-wound)."

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