MolDX: Genetic Testing for Heritable Thoracic Aortic Disease

Genetic testing for heritable thoracic aortic disease is covered for germline testing when the patient has an aortic root or ascending aortic dilation/aneurysm/dissection and at least one qualifying feature (age <60, syndromic features of Marfan/Loeys-Dietz/vascular Ehlers-Danlos, or relevant first- or second-degree family history). Coverage requires documented offer of genetic counseling, that the test includes minimum guideline-based gene content per ClinGen and ACC/AHA, that single-variant testing is limited to known familial variants, and that the assay has completed a MolDX Technical Assessment; tests with unvalidated or unclear-content and those conflicting with repeat-testing policy L38351 are not covered.

"Patient presents with an aortic root or ascending aortic dilation, aneurysm, or dissection as defined by national consensus guidelines."

Sign up to see full coverage criteria, indications, and limitations.